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[...] Even though the carboxylic acid valproate (VPA) is an HDACi with weak inhibitory potential, it is an interesting drug for clinical trials due to its well-characterized pharmacodynamic and pharmacokinetic profile (see Table 6)
Rotating sites systematically prevents this complication
Common side effectsnausea, vomiting, diarrhea, and constipationdepend on dose and can be managed through titration
Thus, the only piece of evidence lacking to draw a similar conclusion for GPX1 is a candidate M pro cleavage site , which most algorithms will fail to find, e.g., if they are highly stringent about requiring a Q in the P1 position (Figure 1)
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